Wilkes improved to 3-4 overall and 3-1 at home while Valley Forge fell to 2-5.
The first 11 points for the Lady Colonels were scored on a Catey McFadden three, Nicole Farrell layup, two layups from Alfano, and a layup by Emily Sofranko in the first 3:01 of action. Wilkes would take a 22-11 lead into the second quarter.
Layups by Farrell and Sierra Smith stretched the Wilkes lead to a game-high 20 points at 35-15 with 6:29 left in the half. The Patriots would cut the lead to 13 points but the Lady Colonels extended the lead back to 16 points and led 44-28 at the end of the second quarter.
Valley Forge went on a 22-11 run to start the third frame to cut the Wilkes lead to five points with 2:02 left in the quarter. Smith answered with a jumper on the next possession and the Lady Colonels finished the quarter on a 6-2 run to lead 61-52.
Wilkes pushed its lead back to 15 points five different times in the fourth quarter and Alfano went 7-of-8 from the free-throw stripe in the final 1:42 to hold the double-digit lead.
Alfano was 8-of-10 overall from the foul line and had five assists. Sofranko scored a career-high 16 points and added four steals. Farrell and Smith also enjoyed career-nights with 12 points each. Farrell added a team-high eight rebounds and Smith also had three assists.
Gianna Roberts, Gabby Smicherko, Maddie Kelley, and Chelsea Erkes all scored six points.
The Patriots were led by 25 points and 15 rebounds from Jhanel Brown. Bailey Mayforth and Alea Flowers added 14 and 11 points respectively and Natalie Cortez registered 11 assists.
The Wilkes bench held a 32-15 scoring advantage and Wilkes also held the 27-8 edge in points off of turnovers in the contest.
The Lady Colonels return to the court Thursday night when they welcome in Penn State Schuylkill to the Marts Center for a 7:00 p.m. tip.
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